Selena Gomez made a purr-fect political reference at the 2024 Emmys on Sunday night.

The singer and actor made a quip about "childless cat ladies," in an apparent reference to Republican Sen. JD Vance's now widely mocked remarks belittling women who don't have children.

During a bit onstage with her "Only Murders in the Building" co-stars Martin Short and Steve Martin, Gomez laughed uncontrollably as Martin and Short playfully fired digs at each other.

The singer then chimed in to share what she loves about her co-stars.

"Let me say what an honor it is to work with two guys who are this far away from being childless cat ladies," she said. (Watch the video here.)

Vance, former President Donald Trump's running mate for the 2024 election, has faced wide scrutiny over comments he made in a resurfaced 2021 interview.

During that interview, he mocked Vice President Kamala Harris, now the Democratic presidential nominee, as one of the "childless cat ladies" who are "miserable" with their lives yet running the country.

People have slammed the senator from Ohio noting that there are many reasons a woman might not have, or might choose not to have, kids. (Harris is a parent to her two stepchildren, Ella and Cole Emhoff.)

Gomez revealed in an interview with Vanity Fair last week that she is unable to carry her own children due to medical reasons.

The actor, who has publicly discussed living with lupus and bipolar disorder, told the publication that she felt "thankful" for having the opportunity to explore other ways she can become a mom in the future, such as via adoption or surrogacy.

Gomez's best friend, pop star Taylor Swift, sparked a media frenzy when she endorsed Harris for president in a statement on social media last week.